Doodlebrary

Doodlebrary

• Development and Initial Use:

• Minoxidil was originally developed in the 1950s as a treatment for ulcers, but it proved ineffective for this purpose​.
• Later, it was repurposed as a vasodilator to treat hypertension (high blood pressure) under the brand name Loniten​.

• Discovery of Hair Growth Effect:

• During trials for hypertension, researchers observed unexpected hair growth as a side effect. This led to its application as a topical treatment for hair loss​.

• Mechanism of Action:

• Minoxidil works by dilating blood vessels, improving blood flow to hair follicles, and prolonging the hair growth phase (anagen phase), which can help regrow hair​.

• FDA Approval for Hair Loss:

• In 1988, the FDA approved Minoxidil for the treatment of male pattern baldness under the brand name Rogaine​.
• It was later approved for use in women in 1991, and today it is available in both 2% and 5% formulations​.

• Forms and Dosages:

• Minoxidil is available in two forms:
  • Topical solution: Applied twice daily (1 mL per application) for men and women​.
  • Foam: Applied once or twice daily, depending on gender and formulation​.

• Side Effects:

• Common side effects include scalp irritation and changes in hair texture​.
• Rare but serious side effects may include unwanted facial hair growth, chest pain, and dizziness if the drug is absorbed into the bloodstream​

• Precautions:

• Minoxidil should not be applied to irritated or infected skin, as this may increase absorption and lead to adverse effects​.
• Pregnant or breastfeeding women should avoid using the drug​.

• Timeframe for Results:

• Visible hair regrowth may take 4 months or longer, and consistent application is necessary to maintain the results​.

• Global Availability:

• Minoxidil is sold under various brand names worldwide, including Rogaine, Regaine, and Mintop​.